Timing of hyperoxic exposure during alveolarization
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چکیده
[PDF] [Full Text] [Abstract] , July 1, 2003; 285 (1): L161-L168. Am J Physiol Lung Cell Mol Physiol G. E. Hosford and D. M. Olson Effects of hyperoxia on VEGF, its receptors, and HIF-2{alpha} in the newborn rat lung [PDF] [Full Text] [Abstract] , February 1, 2004; 286 (2): L411-L419. Am J Physiol Lung Cell Mol Physiol L. B. Clerch, A. S. Baras, G. D. Massaro, E. P. Hoffman and D. Massaro dexamethasone-induced inhibition of alveolar formation DNA microarray analysis of neonatal mouse lung connects regulation of KDR with
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Lung Morphometry, Collagen and Elastin Content: Changes after Hyperoxic Exposure in Preterm Rabbits
INTRODUCTION Elastic and collagen fiber deposition increases throughout normal lung development, and this fiber network significantly changes when development of the lung is disturbed. In preterm rats and lambs, prolonged hyperoxic exposure is associated with impaired alveolarization and causes significant changes in the deposition and structure of elastic fibers. OBJECTIVES To evaluate the e...
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STUDY OBJECTIVE To test the hypothesis that exposure to hyperoxia during the postnatal period of rapid alveolar multiplication by septation would cause permanent impairments, even with moderate levels of hyperoxia. DESIGN We exposed mouse pups to 65% O(2) (hyperoxic mice) or normoxia (normoxic mice) during their first postnatal month, and we analyzed lung histology, pulmonary mechanics, blood...
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BACKGROUND Phosphodiesterase-5 inhibition with sildenafil has been used to treat severe pulmonary hypertension and bronchopulmonary dysplasia (BPD), a chronic lung disease in very preterm infants who were mechanically ventilated for respiratory distress syndrome. METHODS Sildenafil treatment was investigated in 2 models of experimental BPD: a lethal neonatal model, in which rat pups were cont...
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VEGF signaling inhibition decreases alveolar and vessel growth in the developing lung, suggesting that impaired VEGF signaling may contribute to decreased lung growth in bronchopulmonary dysplasia (BPD). Whether VEGF treatment improves lung structure in experimental models of BPD is unknown. The objective was to determine whether VEGF treatment enhances alveolarization in infant rats after hype...
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Supplemental oxygen is frequently used in the treatment of infants having pulmonary insufficiency, but prolonged hyperoxia may contribute to the development of bronchopulmonary dysplasia in these infants. Cytochrome P4501A enzymes have been implicated in hyperoxic lung injury. Retinoic acid (RA) plays a key role in lung development. Here, we tested the hypotheses that newborn rats exposed to a ...
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